| Theme | Molecular biology of colorectal tumors | |
|---|---|---|
| Title | Case of SSA/P with cytological dysplasia | |
| Publish Date | 2018/09 | |
| Author | Bunichiro Kato | Department of Digestive Disease Center, Akita Red Cross Hospital |
| Author | Eiji Harada | Department of Digestive Disease Center, Akita Red Cross Hospital |
| Author | Hiro-o Matsushita | Department of Digestive Disease Center, Akita Red Cross Hospital |
| Author | Kenjiro Yoshikawa | Department of Digestive Disease Center, Akita Red Cross Hospital |
| Author | Yoshihito Tanaka | Department of Digestive Disease Center, Akita Red Cross Hospital / Department of Molecular Diagnostic Pathology, Iwate Medical University, School of Medicine |
| Author | Hiro-o Yamano | Department of Digestive Disease Center, Akita Red Cross Hospital / Department of Gastroenterology, Sapporo Medical University Hospital |
| Author | Takuo Tokairin | Department of Diagnostic Pathology, Akita Red Cross Hospital |
| Author | Katsuhiko Enomoto | Department of Diagnostic Pathology, Akita Red Cross Hospital |
| Author | Eiichiro Yamamoto | Department of Molecular Biology, Sapporo Medical University |
| Author | Hiromu Suzuki | Department of Molecular Biology, Sapporo Medical University |
| [ Summary ] | We report on a case concerning a sessile serrated adenoma/polyp (SSA/P) with cytological dysplasia. The patient was a 70-year-old woman. She had a type Ⅱa lesion (5 mm in diameter) in the transverse colon. The lesion was covered with a mucosal cap. The upper portion of the lesion had protruded. Magnifying endoscopy indicated a Type Ⅱ-open pit pattern in the central and lower part ("barnacle like sign") of the lesion. Type Ⅳ pit patterns were observed in the upper part of the lesion. From these findings, we diagnosed this lesion to be SSA/P with cytological dysplasia. The histopathological diagnosis was 'SSA/P with cytological dysplasia'. We recognized a BRAF mutation in SSA/P and cytological dysplasia areas. We identified a CpG island methylator phenotype in SSA/P and cytological dysplasia areas, but methylation of hMLH1 was found only in the cytological dysplasia area. | |