| Theme | Molecular biology of colorectal tumors | |
|---|---|---|
| Title | Molecular biology of colorectal tumorigenesis | |
| Publish Date | 2018/09 | |
| Author | Hiroyuki Yamamoto | Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine |
| Author | Yoshiyuki Watanabe | Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine / Department of Internal Medicine, Kawasaki Rinko General Hospital |
| Author | Kensuke Tsuji | Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine |
| Author | Masaki Kato | Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine |
| Author | Hirofumi Kiyokawa | Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine |
| Author | Yoshinori Sato | Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine |
| Author | Yasumasa Matsuo | Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine |
| Author | Masaki Yamashita | Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine |
| Author | Hiroshi Yasuda | Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine |
| Author | Fumio Itoh | Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine |
| [ Summary ] | Thirty years have passed since the multistep genetic model for colorectal tumorigenesis was proposed by Vogelstein. Over those years, research on the molecular biology of colorectal tumors has progressed dramatically. Various biomarkers, such as RAS mutations for the selection of molecular targeted therapy, are used in clinical settings. It is necessary for clinicians to understand cancer genome information and to appropriately apply it in clinical settings. The purpose of this review is to summarize the molecular biology of colorectal tumors, including an explanation of technical terms. We have summarized the technical terms used in molecular biology, cancer molecular biology, the basic molecular biology of colorectal tumors, epigenetics/epigenomes, microsatellite instability, microRNA, and clinical application of those molecular alterations as biomarkers along with related topics. | |