| Theme | Recent advance in diagnosis and management of colorectal tumors associated with inflammatory bowel disease | |
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| Title | Update on the pathological diagnosis of ulcerative colitis-associated colorectal neoplasm | |
| Publish Date | 2018/01 | |
| Author | Hiroshi Tanabe | Department of Pathology, Fukuoka University Chikushi Hospital |
| Author | Akinori Iwashita | Department of Pathology, Fukuoka University Chikushi Hospital |
| [ Summary ] | Recently, the number of patients with ulcerative colitis-associated colorectal cancer (UC-CRC) is increasing in Japan. The clinicopathological characteristics of UC-CRC are as follows : relatively occurs in young patients who have multiple lesions, is accompanied by dysplasia, the histological type of the many lesions is very well-differentiated adenocarcinoma with mixed gastric and intestinal mucin phenotype, the carcinoma sporadically infiltrates into the colorectal wall, and the macroscopic type of most lesions is unusual. Immunohistochemically, both carcinomatous cells and non-carcinomatous cells in background mucosa of UC are sometimes positive for 8-OHdG, which is a marker of oxidative damage. Sporadic colorectal cancer (SP-CRC) in patients with UC usually occurs in patients over 60 years of age. An SP-CRC lesion is single, and the macroscopic type of almost all lesions is ulcerative-expansive type. In addition, almost all SP-CRC lesions are immunohistochemically negative for 8-OHdG. There are biological differences between UC-CRC and SPCRC, and it is vital to distinguish them. |
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