| Theme | Reviewing inflammatory diseases of small bowel | |
|---|---|---|
| Title | Small intestinal lesions in familial Mediterranean fever | |
| Publish Date | 2017/11 | |
| Author | Hiroshi Nakase | Department of Gastroenterology and Hepatology, School of Medicine, Sapporo Medical University |
| Author | Tsuyoshi Ogashiwa | Inflammatory Bowel Disease Center, Yokohama City University Medical Center |
| Author | Reiko Kunisaki | Inflammatory Bowel Disease Center, Yokohama City University Medical Center |
| Author | Tomohiro Nagasue | Division of Gastroenterology, Matsuyama Red Cross Hospital / Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author | Shunichi Yanai | Division of Gastroenterology, Department of Internal Medicine, Iwate Medical University |
| Author | Takayuki Matsumoto | Division of Gastroenterology, Department of Internal Medicine, Iwate Medical University |
| Author | Noriyuki Horiki | Department of Endoscopy, Mie University Hospital |
| Author | Kazuki Kakimoto | Second Department of Internal Medicine, Osaka Medical Callege |
| Author | Kazuhide Higuchi | Second Department of Internal Medicine, Osaka Medical Callege |
| [ Summary ] | Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease characterised by repeated peritonitis and fever. Generally, since the primary mechanism of FMF is peritonitis, gastrointestinal mucosal involvement is considered to be a rare condition in FMF patients. Some recent reports have indicated that FMF patients have intestinal lesions mimicking inflammatory bowel disease. However, the reports of small intestinal lesions related to FMF are a few. This review focuses on small intestinal lesions in patients with FMF and discusses endoscopic features. Several reports have suggested that erosions, ulcers, and edema are primarily observed in the small intestine of FMF patients. Interestingly, one report showed petal-shaped mucosal redness with white borders is as a characteristic. Further study of cases of small intestinal lesions in FMF patients is required for elucidation of clinical characteristics. | |