| Theme | Reviewing inflammatory diseases of small bowel | |
|---|---|---|
| Title | Pathogenesis of cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) | |
| Publish Date | 2017/11 | |
| Author | Manabu Nagayama | Division of Gastroenterology, Department of Medicine, Jichi Medical University |
| Author | Tomonori Yano | Division of Gastroenterology, Department of Medicine, Jichi Medical University |
| Author | Hirotsugu Sakamoto | Division of Gastroenterology, Department of Medicine, Jichi Medical University |
| Author | Keijiro Sunada | Division of Gastroenterology, Department of Medicine, Jichi Medical University |
| Author | Hironori Yamamoto | Division of Gastroenterology, Department of Medicine, Jichi Medical University |
| [ Summary ] | Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) is an extremely rare disorder characterized by multiple small intestinal stenoses and ulcers. The lesions resemble NSAID-induced membranous stenoses, causing chronic or relapsing obstructive symptoms. Although systemic corticosteroid therapy seems to be effective, steroiddependency and postsurgical recurrence are major issues. Recently, the relation between prostaglandin metabolism and pathogenesis of CMUSE has been investigated. No cases associated with CMUSE have been reported in Japan. However, it appears that some patients with CMUSE exist in East Asia. Thus, this rare disease is a notable disease and should be considered when small intestinal stenoses and ulcers are observed. | |