| Theme | Reviewing inflammatory diseases of small bowel | |
|---|---|---|
| Title | Clinical features of chronic enteropathy associated with SLCO2A1 gene (CEAS) | |
| Publish Date | 2017/11 | |
| Author | Junji Umeno | Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author | Motohiro Esaki | Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author | Atsushi Hirano | Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author | Shigeyoshi Yasukawa | Department of Gastroenterology, Fukuoka University Chikushi Hospital |
| Author | Fumihito Hirai | Department of Gastroenterology, Fukuoka University Chikushi Hospital |
| Author | Toshiyuki Matsui | Department of Gastroenterology, Fukuoka University Chikushi Hospital |
| Author | Tsuneyoshi Yao | Sada Hospital |
| Author | Takayuki Matsumoto | Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Iwate Medical University |
| [ Summary ] | We retrospectively analyzed the clinical features of 45 patients with chronic enteropathy associated with the SLCO2A1 gene (CEAS). According to the survey, CEAS occurred predominantly in females. It addition, 30 % of the patients had parental consanguinity. Most patients did not manifest symptoms of gross hematochezia but did have signs of anemia. They also exhibited relatively low inflammatory reactions. Small intestinal lesions of CEAS occurred commonly in the ileum (except the terminal ileum). Duodenal lesions were also found in 49 % of the patients. Clinical findings of primary hypertrophic osteoarthropathy such as digital clubbing, periostosis, and pachydermia were found in 30 % of the patients. A comparison of clinical features by gender revealed that gastric involvement was more frequently found in females, while clinical manifestations of primary hypertrophic osteoarthropathy were more frequently observed in males. In addition to endoscopic and radiographic examination of the small intestine, surveillance of upper GI involvement and extra-intestinal manifestation and genetic analysis are considered to be important for diagnosis of the disease. | |