| Series | ||
|---|---|---|
| Title | A case of minute carcinoma with sessile serrated adenoma/polyp | |
| Publish Date | 2017/07 | |
| Author | Eiji Harada | Department of Gastroenterology, Akita Red Cross Hospital |
| Author | Hiro-o Yamano | Department of Gastroenterology, Akita Red Cross Hospital / Department of Gastroenterology of Internal Medicine, Sapporo Medical University |
| Author | Hiro-o Matsushita | Department of Gastroenterology, Akita Red Cross Hospital |
| Author | Kenjiro Yoshikawa | Department of Gastroenterology, Akita Red Cross Hospital |
| Author | Ryo Takagi | Department of Gastroenterology, Akita Red Cross Hospital |
| Author | Yoshihito Tanaka | Department of Gastroenterology, Akita Red Cross Hospital |
| Author | Tamotsu Sugai | Department of Molecular Diagnostic Pathology, Iwate Medical University |
| Author | Makoto Eizuka | Department of Molecular Diagnostic Pathology, Iwate Medical University |
| Author | Eiichiro Yamamoto | Department of Gastroenterology of Internal Medicine, Sapporo Medical University / Department of Molecular Biology, Sapporo Medical University |
| Author | Hiromu Suzuki | Department of Molecular Biology, Sapporo Medical University |
| [ Summary ] | We report a case of minute carcinoma with sessile serrated adenoma/polyp (SSA/P). A colonoscopy was performed to examinine the right abdominal pain in an elderly woman of approximately 70 years of age. The patient presented with a type IIa lesion (5 mm in diameter) that exhibited a mucus adhesion in the transverse colon. Chromoendoscopy findings with indigo carmine revealed a ductal dilation rate from the distal view. Magnifying endoscopy revealed a type II-open pit pattern on the right side of the region and tubular-like pit pattern on the back-side of the region. Although the region occupying the center to the left of the lesion was similar to the tubular pit, it was judged as a type VI pit with a surface structure exhibiting irregularity both on contour and arrangement, but the degree was not strong. From these findings and background, we diagnosed the lesion as a suspected stage Tis, well-differentiated adenocarcinoma with SSA/P. We performed endoscopic mucosal resection (EMR), and made a histological diagnosis of carcinoma with SSA/P. We performed gene analysis for the lesion and recognized BRAF mutation and CIMP in all parts of the carcinoma. |
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