| Theme | Impacts of intestinal microbiota | |
|---|---|---|
| Title | Pathological function of intestinal microbiota in inflammatory bowel disease | |
| Publish Date | 2017/07 | |
| Author | Shinta Mizuno | Division of Gastroenterology and Hepatology, Keio University School of Medicine |
| Author | Takanori Kanai | Division of Gastroenterology and Hepatology, Keio University School of Medicine |
| [ Summary ] | Various strains of microbiota inhabit the human intestinal tract. Imbalances in the composition of the intestinal microbiota (dysbiosis) is associated with various gastrointestinal diseases, autoimmune diseases, and metabolic syndrome. Analysis of the intestinal microbiota using next-generation sequencers has demonstrated the association between inflammatory bowel disease (IBD) and dysbiosis, as well as increased immunological stimulation and mucosal barrier dysfunctions. Thus, inducing symbiosis of intestinal microbiota may have therapeutic potentials for gastrointestinal diseases. However, there are currently limited therapeutic options other than probiotics. The induction of symbiosis in patients with IBD through microbiota therapy is challenging. | |