| Theme | Tips and up-to-date of the medical therapy for ulcerative colitis | |
|---|---|---|
| Title | 5-Aminosalicylates and steroid therapy | |
| Publish Date | 2016/07 | |
| Author | Shunsuke Komoto | Department of Endoscopic and Photodynamic Medicine, National Defense Medical College / Department of Internal Medicine, National Defense Medical College |
| Author | Ryota Hokari | Department of Internal Medicine, National Defense Medical College |
| [ Summary ] | 5-Aminosalicylates (5-ASA) and steroids have key roles in the treatment of ulcerative colitis (UC). Several types of drug delivery systems are currently available for 5-ASA, such as time-dependent release and pH-dependent release. They are used according to the extent of the disease. Although all types of 5-ASA can be used for both induction and maintenance therapy, allergic responses to mesalazine are a concern. On the other hand, steroids are the first choice for treating moderate and severe UC；however, they should not be used for maintenance therapy. When one begins to administer steroids, one should have a plan regarding how and when to stop. Major side effects of steroids, such as osteoporosis, diabetes, and infections, should be noted. | |