| Theme | Gastrointestinal polyposis -- progress in the diagnosis and treatment | |
|---|---|---|
| Title | Familial adenomatous polyposis : prevention of colorectal cancer | |
| Publish Date | 2016/05 | |
| Author | Hideki Ishikawa | Department of Molecular-Targeting Cancer Prevention, Kyoto Prefectural University of Medicine |
| [ Summary ] | Until recently, total colectomy was the only option to prevent progression from familial adenomatous polyposis (FAP) to colon cancer. To avoid colectomy or prolong the time to surgery, studies have been conducted on chemoprevention for suppression of the growth of colorectal polyps and on treatment with endoscopic polypectomy. This report presents the results of clinical studies with non-steroidal anti-inflammatory drugs such as sulindac, celecoxib, and aspirin on chemoprophylaxis against progression from FAP to colon cancer, and recent progress of research on thorough endoscopic polypectomy. Chemoprevention therapy and endoscopic polypectomy have not been sufficiently studied for clinical use in FAP, but may become practical options for treatment of some types of FAP in the near future. |
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