| Theme | "Early Colorectal Cancer" and "Intestine", Road to future | |
|---|---|---|
| Title | Colorectal serrated polyps : Current knowledge and future prospects | |
| Publish Date | 2016/01 | |
| Author | Shuichiro Nagata | Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine / Department of Endoscopy, Kurume University School of Medicine |
| Author | Osamu Tsuruta | Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine / Department of Endoscopy, Kurume University School of Medicine |
| Author | Hiroshi Kawano | Unit of Gastroenterology, St. Mary's Hospital |
| Author | Yasuhiko Maeyama | Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine / Department of Endoscopy, Kurume University School of Medicine |
| Author | Tsutomu Nagata | Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine / Department of Endoscopy, Kurume University School of Medicine |
| Author | Michita Mukasa | Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine / Department of Endoscopy, Kurume University School of Medicine |
| Author | Jun Akiba | Division of Pathology, Kurume University School of Medicine |
| Author | Keiichi Mitsuyama | Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine / Department of Endoscopy, Kurume University School of Medicine |
| Author | Takuji Torimura | Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine / Department of Endoscopy, Kurume University School of Medicine |
| [ Summary ] | The histopathology of colonic serrated lesions is generally classified into three categories : hyperplastic polyp (HP), sessile serrated adenoma/polyp (SSA/P), and traditional serrated adenoma (TSA). SSA/P resembles HP, but is one of the outrider lesions of the microsatellite instability (MSI) positive colorectal cancers on the right side of the colon. Unlike HP, at a point having the structure variant and the cell variant. This is a significant finding for the endoscopic diagnosis of SSA/P, type II-open pit pattern and VMV in NBI magnified observation. Since there is no established theory about how the criteria of SSA/P should be used in endoscopic treatment, this has important clinical implications. It is known that tubular adenoma like structures and TSA like structures are generated from a part of the SSA/P ; these are expressed as SSA/P with cytological dysplasia in the WHO classification. In the future, we need to integrate these serrated lesions and study the malignant transformation rate, the endoscopic findings, the clinicopathological features, and the molecular biological features of the cancer coexisting lesions, and continue to clarify the essence of the colorectal serrated lesions. | |