| Theme | "Early Colorectal Cancer" and "Intestine", Road to future | |
|---|---|---|
| Title | Diagnostic pathology of colorectal carcinoma in Japan : a historical perspective and recent advances | |
| Publish Date | 2016/01 | |
| Author | Atsuko Ota | Department of Pathology, Fukuoka University Chikushi Hospital |
| Author | Akinori Iwashita | Department of Pathology, Fukuoka University Chikushi Hospital |
| Author | Keisuke Ikeda | Department of Pathology, Fukuoka University Chikushi Hospital |
| Author | Hiroshi Tanabe | Department of Pathology, Fukuoka University Chikushi Hospital |
| [ Summary ] | In Japan, the first step of pathological diagnoses of colorectal carcinoma involves diagnosing the surgically resected specimens. Following this, other diagnostic methods, such as those involving biopsies by colonoscopy as well as specimens obtained by endoscopic resection, polypectomy, or endoscopic mucosal resection (EMR), are used. along with the recent inclusion of other approaches such as diagnoses of early colorectal cancer by endoscopic submucosal dissection (ESD). The rapid development of diagnostics and therapeutics of clinical importance have led to advances in pathological diagnoses. Two different theories regarding the development of colorectal cancer have been under a long-standing debate. When the adenoma-carcinoma sequence theory was dominant, the discovery of a flat or depressed early colorectal cancer laid attention to the existence of "de novo" cancers. The current common understanding is that both oncogenic pathways exist. We also outlined the differences in the diagnostic criteria for diagnoses of colorectal epithelial neoplasms among pathologists, rationale for such differences, differences in the diagnostic criteria between Japanese and Western pathologists, and establishing a consensus classification (Vienna classification) on the basis of such differences. | |