| Theme | Histopathological Diagnosis IIc Type of Colorectal Cancer | |
|---|---|---|
| Title | Imuunihistochemical examination in the diagnosis of coloreetal IIc-type neoplasia | |
| Publish Date | 1998/03 | |
| Author | Ryo Wada | Department of Pathology, Kanto Rosai Hospital |
| [ Summary ] | Some immunohistochemical examinations play important roles in the diagnosis of colorectal neoplasias, including the IIc-type lesion, the whose detection of which currently increasing. For example, anti-brornodeoxyuridine staining (BrdU), anti-proliferative cell nuclear antigen staining (PCNA) and anti-p53 staining (p53) are useful for differential diagnosis of benign versus malignant in colorectal neoplasia. Usually, neoplastic cells positive for BrdU or PCNA are seen diffusely in colorectal invasive adenocarcinoma. On the other hand, neoplastic cells positive for BrdU are usually located in tubular (or tubulovillous) adenoma in the upper portion of the neoplastic tubules. Furthermore, the avelage number of positive neoplastic cells is greater in the adenocarcinoma lesions than in adenoma lesions. While neoplastic cells positive for p53 are seen diffusely in the colorectal invasive adenocarcinoma lesions, these cells are absent or seen only sparsely in adenornatous lesions. On occasion these findings are useful for the differential diagnosis of colorectal IIc. However, these stains also can not distinguish between intramucosal adenocarcinoma lesions with only low grade-histological atypia and adenomatous lesions with high grade-histological atypia. |
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