| Theme | Intestinal malignant lymphoma | |
|---|---|---|
| Title | Diagnosis and treatment of primary diffuse large B-cell lymphoma of the intestinal tract | |
| Publish Date | 2015/05 | |
| Author | Masahiro Tajika | Departments of Endoscopy, Aichi Cancer Center Hospital |
| Author | Tsuneya Nakamura | Nakamura Clinic |
| Author | Tsutomu Tanaka | Departments of Endoscopy, Aichi Cancer Center Hospital |
| Author | Makoto Ishihara | Departments of Endoscopy, Aichi Cancer Center Hospital |
| Author | Tomohiro Kinoshita | Hematology and Cell Therapy, Aichi Cancer Center Hospital |
| Author | Yasushi Yatabe | Pathology and Molecular Diagnosis, Aichi Cancer Center Hospital |
| Author | Kenji Yamao | Gastroenterology, Aichi Cancer Center Hospital |
| Author | Yasumasa Niwa | Departments of Endoscopy, Aichi Cancer Center Hospital |
| [ Summary ] | Although primary intestinal diffuse large B-cell lymphoma (DLBCL) is a rare disease, its incidence is increasing. Computed tomography (CT) scan and barium enema have shown high sensitivity and specificity in detecting small bowel diseases, including DLBCL. The newer techniques of positron emission tomography-CT, capsule endoscopy, and double balloon endoscopy have also proven useful in the diagnosis of intestinal DLBCL. Furthermore, histological diagnosis complemented by molecular biology methods is recommended to make a precise diagnosis. Surgical resection followed by 6 cycles of R-CHOP is recommended for the patients with localized intestinal DLBCL. In patients with advanced DLBCL, 6 to 8 cycles of R-CHOP are recommended. | |