| Series | ||
|---|---|---|
| Title | Case of Carcinoma in sessile serrated adenoma/polyp | |
| Publish Date | 2014/05 | |
| Author | Yoshihito Tanaka | Department of Gastroenterology, Akita Red Cross Hospital |
| Author | Hiro-o Yamano | Department of Gastroenterology, Akita Red Cross Hospital |
| Author | Tamotsu Sugai | Division of Diagnostic Molecular Pathology, Department of Pathology, Iwate Medical University |
| Author | Eiichiro Yamamoto | 1st Department of Internal Medicine, Department of Molecular Biology, Sapporo Medical University |
| [ Summary ] | We report on a case of carcinoma in sessile serrated adenoma/polyp. The patient was a woman of 60 years old. She had a protruded lesion 10 mm in size in the ascending colon. Magnifying endoscopy indicated TypeII-open pit patterns in most of the lesion. However, Type VI pit patterns were observed in the top of the lesion. From these findings, we diagnosed this lesion as carcinoma in sessile serrated adenoma/polyp. Endoscopic mucosal resection (EMR) was perfomed. Histological diagnos is was as follows : moderately differentiated adenocarcinoma (Tis) in sessile serrated adenoma/polyp, ly0, v0, HM0, VM0. We performed gene analysis of this lesion. We recognized BRAF mutation and CIMP in both sections of the carcinoma and SSA/P, but methylation of MLH1 was found only in the carcinomial section. It was thought that this lesion was an MSI-positive colon carcinoma which occurred due to SSA/P. | |