| Theme | Laterally spreading tumor (LST) -- Toward a new era | |
|---|---|---|
| Title | Genetic characteristics of laterally spreading tumors | |
| Publish Date | 2014/01 | |
| Author | Sakiko Hiraoka | Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences |
| Author | Keita Harada | Department of Endoscopy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, |
| Author | Jun Kato | Second Department of Internal Medicine, Wakayama Medical University |
| [ Summary ] | Each granular type of laterally spreading tumor (LST-G), including non-granular type LST (LSTNG) and sessile serrated adenoma/polyp (SSA/P), are characterized by superficial expansion along the colonic lumen. They are considered to have unique genetic characteristics associated with carcinogenesis. RAS/RAF/MAPK signals and the frequency of DNA methylation have been shown to be involved in correlations between morphologic difference in LSTs and genetic alterations. The representative molecular changes of LST-G, LST-NG, and SSA/P are K-ras mutation/CIMP-low, K-ras wild/BRAF wild/CIMP-negative, and BRAF mutation/CIMP-high, respectively. | |