| Theme | Laterally spreading tumor (LST) -- Toward a new era | |
|---|---|---|
| Title | Clinicopathological findings and molecular alterations of colorectal laterally spreading tumors | |
| Publish Date | 2014/01 | |
| Author | Tamotsu Sugai | Division of Molecular Diagnostic Pathology, Department of Pathology, School of Medicine, Iwate Medical University |
| Author | Noriyuki Uesugi | Division of Molecular Diagnostic Pathology, Department of Pathology, School of Medicine, Iwate Medical University |
| Author | Ryo Sugimoto | Division of Molecular Diagnostic Pathology, Department of Pathology, School of Medicine, Iwate Medical University |
| Author | Hiro-o Yamano | Division of Gastroenterology, Akita Red Cross Hospital |
| Author | Ryou Takagi | Division of Gastroenterology, Akita Red Cross Hospital |
| Author | Toshimi Chiba | Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University |
| Author | Takayuki Matsumoto | Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University |
| [ Summary ] | In general, colorectal laterally spreading tumors (LST) are classified into the LST-G and LST-NG categories. Previous studies have shown that colorectal LSTs have distinct clinicopathological features and a high potential for malignancy. The aims of this study are to review clinicopathological features and molecular findings related to colorectal LSTs. There is a significant diff erence in tumor location and histological type between LST-Gs and LST-NGs. On the other hand, the frequency of submucosal cancer is high in the specific types of LSTs. Whereas there was a high frequency of ki-ras and APC mutations found in the LST-G types, distinct molecular features were not found in LST-NGs. 5q LOH was a common molecular feature in both LSTGs and LST-NGs. Molecular and clinicopathological findings suggest that LST-Gs and LST-NGs exhibit different aspects of colorectal tumorigenesis. | |