| [ Summary ] |
In the first report concerning Lynch syndrome, Henry T. Lynch described the disease as a "Cancer Family Syndrome", which is characterized by the onset of miscellaneous malignant neoplasms, comprised of carcinomas in the colorectum, endometrium, ovary, ureter, renal pelvis, small intestine, etc. Unlike western countries, stomach cancer occupies an integral part of Lynch syndrome related cancer in Asian countries such as Japan and Korea, where the incidence of stomach cancer is higher than those of western countries. This article reviews Lynch syndrome related cancer other than colorectal cancer, focusing on their lifetime risk, genotype-phenotype correlation, clinical management and surveillance. |