| Theme | How should we interpret sessile serrated adenoma/polyp ? | |
|---|---|---|
| Title | Molecular pathogenesis of sessile serrated adenoma/polyp | |
| Publish Date | 2012/11 | |
| Author | Eiichiro Yamamoto | 1st Department of Internal Medicine, Sapporo Medical University / Department of Molecular Biology, Sapporo Medical University |
| Author | Reo Maruyama | Department of Molecular Biology, Sapporo Medical University |
| Author | Tomoaki Kimura | Division of Gastroenterology, Akita Red Cross Hospital |
| Author | Hiro-o Yamano | Division of Gastroenterology, Akita Red Cross Hospital |
| Author | Tomotsu Sugai | Department of Diagnostic Pathology, Iwate Medical University School of Medicine |
| Author | Yasuhisa Shinomura | 1st Department of Internal Medicine, Sapporo Medical University |
| Author | Hiromu Suzuki | Department of Molecular Biology, Sapporo Medical University |
| [ Summary ] | Integrated analysis of endoscopic, histological and molecular signatures indicates that surface microstructures observed using magnifying endoscopy reflect histological changes as well as genetic and epigenetic defects. Our analysis revealed Type II-Open pit patterns, which are highly specific to SSA/Ps with BRAF mutation and CIMP. | |