| Theme | How should we interpret sessile serrated adenoma/polyp ? | |
|---|---|---|
| Title | Molecular features of hyperplastic polyps and SSA/Ps | |
| Publish Date | 2012/11 | |
| Author | Kazuo Konishi | Division of Gastroenterology, Department of Medicine, Showa University School of Medicine |
| Author | Yutaro Kubota | Division of Gastroenterology, Department of Medicine, Showa University School of Medicine |
| Author | Yuichiro Yano | Division of Gastroenterology, Department of Medicine, Showa University School of Medicine |
| Author | Atsushi Katagiri | Division of Gastroenterology, Department of Medicine, Showa University School of Medicine |
| Author | Takashi Muramoto | Division of Gastroenterology, Department of Medicine, Showa University School of Medicine |
| Author | Yoshiya Kobayashi | Division of Gastroenterology, Department of Medicine, Showa University School of Medicine |
| Author | Masayuki Tojo | Division of Gastroenterology, Department of Medicine, Showa University School of Medicine |
| Author | Kenichi Konda | Division of Gastroenterology, Department of Medicine, Showa University School of Medicine |
| Author | Kensuke Shinmura | Division of Gastroenterology, Department of Medicine, Showa University School of Medicine |
| Author | Toshiko Yamochi | Department of Pathology, Clinico-diagnostic Pathology, Showa University School of Medicine |
| [ Summary ] | A total of 110 serrated polyps were histologically classified into four groups ; 13 goblet-cell rich type hyperplastic polyps (GCHPs), 32 microvesicular type HPs (MVHPs), 18 HP-SSA/Ps and 47 SSA/Ps. We compared the clinicopathological and molecular findings in four groups. SSA/Ps were more frequently located in the proximal colon. Tumor size increased with histological grade in MVHPs, HP-SSA/Ps and SSA/Ps. The frequency of BRAF mutation was significantly higher in MVHPs, HP-SSA/Ps and SSA/Ps, compared to GCHPs. However, there was no significant difference in the frequency of BRAF mutations between proximal and distal lesions. CIMP was found in all groups except GCHPs. The frequency of CIMP was higher in proximal rather than distal lesions. We suggest that proximal MVHPs may develop through the progression of HP-SSA/Ps to SSA/Ps, accompanying BRAF mutation and CIMP. | |