| Theme | Intestinal ulcerations related to vascular disorders | |
|---|---|---|
| Title | Intestinal manifestations in systemic lupus erythematosus | |
| Publish Date | 2012/09 | |
| Author | Yuji Maehata | Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author | Koichi Asano | Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author | Motohiro Esaki | Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author | Takayuki Matsumoto | Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| [ Summary ] | Gastrointestinal symptoms are common in systemic lupus erythematosu (SLE). Intestinal lesions are classified into lupus enteritis (multiple ulcer type and ischemic enteritis type) and protein-losing gastroenteropathy. In the multiple ulcer type, punched-out ulcers are found in the distal colon. In contrast, the ischemic enteritis type is characterized by diffuse submucosal edema in the small intestine. Protein-losing gastroenteropathy results in hypoproteinemia. Steroid therapy is effective for the ischemic enteritis type and protein-losing gasroenteropathy. However, the multiple ulcer type is intractable to medication, and it often causes intestinal perforations. | |