| Theme | Small colorectal cancer with high malignant potential | |
|---|---|---|
| Title | Molecular characteristics of small carcinomas and precursor colorectal lesions | |
| Publish Date | 2012/07 | |
| Author | Kazuo Konishi | Division of Gastroenterology, Department of Medicine, Showa University School of Medicine |
| Author | Atsushi Katagiri | Division of Gastroenterology, Department of Medicine, Showa University School of Medicine |
| Author | Yutaro Kubota | Division of Gastroenterology, Department of Medicine, Showa University School of Medicine |
| Author | Takashi Muramoto | Division of Gastroenterology, Department of Medicine, Showa University School of Medicine |
| Author | Yuichiro Yano | Division of Gastroenterology, Department of Medicine, Showa University School of Medicine |
| Author | Yoshiya Kobayashi | Division of Gastroenterology, Department of Medicine, Showa University School of Medicine |
| Author | Masayuki Tojyo | Division of Gastroenterology, Department of Medicine, Showa University School of Medicine |
| Author | Kenichi Konda | Division of Gastroenterology, Department of Medicine, Showa University School of Medicine |
| Author | Kensuke Shinmura | Division of Gastroenterology, Department of Medicine, Showa University School of Medicine |
| Author | Toshiko Yamochi | Department of Pathology, Showa University School of Medicine |
| Author | Michio Imawari | Division of Gastroenterology, Department of Medicine, Showa University School of Medicine |
| [ Summary ] | Small colorectal cancers (CRCs) are thought to develop via de novo type pathways. They demonstrate different molecular and biological features, compared to other CRCs, which develop through adenoma-carcinoma sequences. Depressed neoplasms may be precursor lesions of de novo carcinoma. However, when we evaluate the molecular findings of mucosal lesions (dysplasias) and Dukes' A cancers by macroscopic type or growth type, some discordance in molecular findings between dysplasias and cancers is observed. These findings suggest the diversity of colorectal tumorigenesis. Further investigation is needed to clarify this issue. | |