| Theme | Invasive colorectal cancer current status and practical issues of depth 1,000μm | |
|---|---|---|
| Title | Pathological problem associated with permeation distance of 1,000μm in relation to colorectal SM invasive cancer | |
| Publish Date | 2012/03 | |
| Author | Shigeharu Hamatani | Department of Pathology, Showa University Northern Yokohama Hospital |
| Author | Shin-ei Kudo | Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author | Hideyuki Miyachi | Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author | Nobunao Ikehara | Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author | Kazuo Ohtsuka | Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author | Eiji Hidaka | Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author | Fumio Ishida | Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author | Shungo Endo | Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author | Junichi Tanaka | Digestive Disease Center, Showa University Northern Yokohama Hospital |
| [ Summary ] | One factor which should be considered for additional treatment after endoscopic resection of colorectal SM invasive cancer is SM permeation levels of 1,000μm or more. The permeation distance into the muscularis mucosae (MM) as a virtual line measurement provides incontrovertible evidence of this condition. When it is less than 1,000μm and the distance of the surface measured is 1,000μm or more, a judgment of SM deep permeation as determined by the pathologist’s may be considered to be indisputable. An increase in the permeation distance was not reflected in the LN metastatic rate according to analysis of the effects of SM invasive cancer. However, determination was influenced by the appearance of tumor budding and vessel invasion rates. It seems that an analysis of the state of MM using desmin immunostaining will become a convenient classification tool. | |