| Theme | Drug-induced gastrointestinal disorders | |
|---|---|---|
| Title | Nonsteroidal anti-inflammatory drugs-induced colopathy | |
| Publish Date | 2012/01 | |
| Author | Koichi Kurahara | Division of Gastroenterology, Matsuyama Red-cross Hospital |
| Author | Takayuki Matsumoto | Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author | Yumi Oshiro | Division of Pathology, Matsuyama Red-cross Hospital |
| Author | Takashi Yao | 4Department of Human Pathology, Juntendo University School of Medicine |
| Author | Mitsuo Iida | Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University / Department of Internal Medicine, Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers |
| [ Summary ] | Nonsteroidal anti-inflammatory drugs (NSAIDs) induce a broad spectrum of toxicologic manifestations throughout the gastrointestinal tract, including the large intestine. NSAID-induced colopathy includes two distinctive conditions : discrete ulcerations with or without diaphragm-like strictures, and hemorrhagic or aphthoid colitis. While diaphragm-like strictures have been known to be the most characteristic feature of the colonic lesions, NSAID-induced colonic ulceration is regarded to be an early stage of stricture formation. When frank ulceration or colitis is found anywhere within the colorectum early diagnosis of the disease, should be conducted an NSAID use should be investigated. Further epidemiological studies and therapeutic trials are warranted to clarify NSAID-induced colopathy. | |