| Theme | Drug-induced gastrointestinal disorders | |
|---|---|---|
| Title | Low-dose aspirin induced small bowel injury | |
| Publish Date | 2012/01 | |
| Author | Kazuhiro Mizukami | Department of Gastroenterology, Oita University Faculty of Medicine |
| Author | Yuka Hirashita | Department of Gastroenterology, Oita University Faculty of Medicine |
| Author | Akari Hisamatsu | Department of Gastroenterology, Oita University Faculty of Medicine |
| Author | Ryo Ogawa | Department of Gastroenterology, Oita University Faculty of Medicine |
| Author | Masahiro Uchida | Department of Gastroenterology, Oita University Faculty of Medicine |
| Author | Yoshifumi Nakagawa | Department of Gastroenterology, Oita University Faculty of Medicine |
| Author | Tadayoshi Okimoto | Department of Gastroenterology, Oita University Faculty of Medicine |
| Author | Masaaki Kodama | Department of Gastroenterology, Oita University Faculty of Medicine |
| Author | Kazunari Murakami | Department of Gastroenterology, Oita University Faculty of Medicine |
| [ Summary ] | Previous studies have shown NSAIDs (including aspirin) induce small bowel injury. Capsule endoscopy and balloon enteroscopy have made possible the detection of small intestinal lesions. Low-dose aspirin is the main antiplatelet drug for many patients with cardiovascular and cerebrovascular diseases. Recently, Japanese studies have reported that misoprostol and rebamipide are effective for treatment and prevention of aspirin induced small bowel injury. Further studies are required to determine optimal prophylaxis and treatment strategies for patients as soon as possible. | |