| Theme | Intestinal mucosal immunology update for clinician | |
|---|---|---|
| Title | IL-17 A-producing cells in the pathogenesis of IBD | |
| Publish Date | 2011/09 | |
| Author | Takanori Kanai | Department of Internal Medicine, School of Medicine, Keio University |
| Author | Tomohisa Sujino | Department of Internal Medicine, School of Medicine, Keio University |
| Author | Yohei Mikami | Department of Internal Medicine, School of Medicine, Keio University |
| Author | Toshifumi Hibi | Department of Internal Medicine, School of Medicine, Keio University |
| [ Summary ] | The hypothesis of Th1/Th2 cytokine balance is often invoked to explain the development of inflammatory bowel diseases (IBD). Recently, however, newly identified Th17 cells, which produce Th17 family cytokines, have come to be recognized as an essential subpopulation in the development of IBD. Furthermore, a representative Th17 family cytokine, IL-17A, is known to be produced by other types of cells, such as TCRgd T cells, NKT cells, NK cells, and innate lymphoid cells (ILCs), which may be also critically involved in the initiation and persistence of IBD. We here review recent findings of IL-17 A-producing cells in the pathogenesis of IBD. | |