| Theme | Intestinal mucosal immunology update for clinician | |
|---|---|---|
| Title | Involvement of anti-microbial peptide dysfunction in IBD pathogenesis | |
| Publish Date | 2011/09 | |
| Author | Takahiro Ito | Division of Gastroenterology and Hematology / Oncology, Department of Medicine, Asahikawa Medical University |
| Author | Mikihiro Fujiya | Division of Gastroenterology and Hematology / Oncology, Department of Medicine, Asahikawa Medical University |
| Author | Kentaro Moriichi | Division of Gastroenterology and Hematology / Oncology, Department of Medicine, Asahikawa Medical University |
| Author | Kotaro Okamoto | Division of Gastroenterology and Hematology / Oncology, Department of Medicine, Asahikawa Medical University |
| Author | Hiroki Tanabe | Division of Gastroenterology and Hematology / Oncology, Department of Medicine, Asahikawa Medical University |
| Author | Atsuo Maemoto | IBD Center, Sapporo Higashi Tokushukai Hospital |
| Author | Toshifumi Ashida | IBD Center, Sapporo Higashi Tokushukai Hospital |
| Author | Tokiyoshi Ayabe | Innate Immunity Laboratory, Department of Cellular Life Science, Faculty of Advanced Life Science, Hokkaido University |
| Author | Yutaka Kohgo | Division of Gastroenterology and Hematology / Oncology, Department of Medicine, Asahikawa Medical University |
| [ Summary ] | Paneth cells play a central role in intestinal innate immunity through the secretion of anti-microbial peptides. The expression of α-defensin, an anti-microbial peptide, is known to decrease in patients with Crohn's disease. This suggests the significance of altered anti-microbial peptide functions in the etiology of inflammatory bowel disease (IBD). α-defensin exhibits anti-microbial activity, while also enhancing the migration of immature dendritic cells. It also aids induction of the secretion of interleukin-8 from the intestinal epithelia. These actions contribute to the regulation of acquired immunity. This review describes the detailed function of anti-microbial peptides in innate and acquired immunity. It also offers novel insights into the involvement of anti-microbial peptide dysfunction in the pathogenesis of IBD. | |