| Theme | Intestinal mucosal immunology update for clinician | |
|---|---|---|
| Title | Recent progress in basic research concerning mucosal immunology -- from bench to bedside | |
| Publish Date | 2011/09 | |
| Author | Hideki Iijima | Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine |
| Author | Hiroshi Kiyono | Division of Mucosal Immunology, The Institute of Medical Science, The University of Tokyo |
| [ Summary ] | Dysregulation of the mucosal immune system is thought to be one causative mechanism which contributes to inflammatory bowel diseases (IBD). The induction site in the mucosal immune system (e.g., Peyer's patches) can be used to effectively control subsequent induction and regulation of mucosal immune responses. The ontogeny of Peyer's patches has been characterized and indigenous opportunistic bacteria are found to inhabit Peyer's patches. In the mucosal immune system, regulatory T cells can be effectively induced. These contribute to the creation of mutually beneficial conditions between the host immune system and gut environments, including commensal microorganisms and foods. Further analysis of mucosal immunity will help in the development of new prevention and therapeutic strategies for IBD. | |