| Theme | Mystery concerning the lower rectum | |
|---|---|---|
| Title | Clinicopathological characteristics of advanced rectal cancer and colon cancer | |
| Publish Date | 2010/11 | |
| Author | Hiroaki Ikematsu | Department of Gastroenterology & Gastrointestinal Oncology, National Cancer Center Hospital East |
| Author | Yusuke Yoda | Department of Gastroenterology & Gastrointestinal Oncology, National Cancer Center Hospital East |
| Author | Yasuhiro Oono | Department of Gastroenterology & Gastrointestinal Oncology, National Cancer Center Hospital East |
| Author | Yusuke Nishizawa | Department of Gastroenterology & Gastrointestinal Oncology, National Cancer Center Hospital East |
| Author | Kazuhiro Kaneko | Department of Gastroenterology & Gastrointestinal Oncology, National Cancer Center Hospital East |
| Author | Norio Saito | Department of Gastroenterology & Gastrointestinal Oncology, National Cancer Center Hospital East |
| [ Summary ] | The number of colorectal cancer cases is increasing yearly. The incidence of lesions detected early on in the right side of the colon is higher than the number of advanced cancers. However, advanced cancer of the rectum is frequently detected. As a result, we compared the clinicopathologcal characteristics of advanced rectal cancer lesions with those of advanced colon cancer lesions. From January, 2000 to November, 2009 at the National Cancer Center Hospital East, 1,843 lesions received surgical treatment for advanced colorectal cancer was enrolled in this study. There were 683 lesions with rectal cancer, and 1,160 with colon cancer. There were many men with advanced rectal cancer, and a number of symptomatic patients. The mean size of advanced rectal cancer lesions was significantly larger than those lesions in the colon (p=0.009). Advanced rectal cancer lesions often involved muscle layer invasion. There was significantly more venous invasion in advanced rectal cancer lesions than in advanced colon cancer lesions (p<0.001). Major recurrent sites for advanced rectal cancer involved local recurrence in 3.7 % of patients, livers 10.2 %, and lungs 6.0%. Rates for advanced colon cancer were 1.2 %, 13.2 % and 2.5 % for the above mentioned. In conclusion, we hypothesize that advanced rectal and colonic cancer may be of different natures. |
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