| Theme | Mystery concerning the lower rectum | |
|---|---|---|
| Title | Early colorectal cancer : comparison of clinical rectal cancer and colon cancer features | |
| Publish Date | 2010/11 | |
| Author | Nobunao Ikehara | Division Disease Center, Showa University Northern Yokohama Hospital |
| Author | Shin-ei Kudo | Division Disease Center, Showa University Northern Yokohama Hospital |
| Author | Yasuharu Maeda | Division Disease Center, Showa University Northern Yokohama Hospital |
| Author | Hideyuki Miyachi | Division Disease Center, Showa University Northern Yokohama Hospital |
| Author | Kunihiko Wakamura | Division Disease Center, Showa University Northern Yokohama Hospital |
| Author | Yoshiki Wada | Division Disease Center, Showa University Northern Yokohama Hospital |
| Author | Kazuo Otsuka | Division Disease Center, Showa University Northern Yokohama Hospital |
| Author | Shigeharu Hamatani | Department of Pathology, Showa University Northern Yokohama Hospital |
| [ Summary ] | The incidence of colorectal cancer is increasing in Japan. Clearly, preventing, detecting and treating colorectal cancer in the early stages is of utmost importance. However, few early colorectal cancer cases can be detected in spite of the high number of advanced colorectal cancers which are eventually detected. The aim of our study was to demonstrate the characteristics of early rectal cancer as compared to early colon cancer. A total of 2,205 early colorectal cancers, including 532 submucosal invasive cancers, were resected endoscopically or surgically from April 2001 to Deccember 2009 at our facility. We pathologically diagnosed massively invasive submucosal lesions, using Kudo's classification of the degree of submucosal invasion. Their gross appearance was devided into the following categories ; protruded, flat, and depressed type. IIc and IIc+IIa leasions had lower incidence rates in the rectum. LST lesions in the rectum, especially LST granular-nodular mixed type, exhibited a higher incidence than those types in the colon. Submucosal invasive cancers in the rectum exhibited significantly high incidences of vessel infiltration (p=0.00477) and submucosal massive invasion (p=0.00753). These results indicate that depressed type cancer in the rectum may not be visible in the early phases of carcinogenesis. |
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