| Theme | Revaluation of de nove cancer | |
|---|---|---|
| Title | Molecular carcinogenesis of de novo type of colorectal cancers? | |
| Publish Date | 2009/07 | |
| Author | Tamotsu Sugai | Department of Diagnostic Pathology, School of Medicine Iwate Medical University |
| Author | Risaburo Akasaka | Department of Diagnostic Pathology, School of Medicine Iwate Medical University / Department of Gastroenterology and Hepatology, School of Medicine Iwate Medical University |
| Author | Yasuhiro Konishi | Department of Diagnostic Pathology, School of Medicine Iwate Medical University |
| Author | Yoshiharu Mue | Department of Diagnostic Pathology, School of Medicine Iwate Medical University |
| Author | Toshimi Chiba | Department of Diagnostic Pathology, School of Medicine Iwate Medical University |
| Author | Hiro-o Yamano | Division of Gastroenterology, Akita Red Cross Hospital |
| Author | Koki Ohtsuka | Department of Surery, School of Medicine Iwate Medical University |
| Author | Tsuyoshi Wakabayashi | Department of Surery, School of Medicine Iwate Medical University |
| Author | Kazuyuki Suzuki | Department of Gastroenterology and Hepatology, School of Medicine Iwate Medical University |
| [ Summary ] | Recently, it has become clear that colorectal cancer (CRC) evolves through multiple pathways. These pathways are defined in relation to four type of precancerous lesions: 1）adenoma-carcinoma-sequence pathways, 2）de novo type cancer pathways, 3）serrated pathways and 4）inflammatory carcinogenesis pathways. In this review the molecular characteristics of de novo type cancer pathways are outlined. In general, de novo type tumors are thought to be of the depressed type. It has been clarified that although the frequency of mutations of K-ras and APC genes in depressed tumors is low, compared with polypoid type tumors, mutation or overexpression of the p53 gene is frequently found in depressed tumors. However, little is known regarding the role of methylation in depressed tumors. Molecular elucidation of de novo type cancer would accelerate understanding of CRC carcinogenesis and would have an impact on clinical management for both prevention and treatment. | |