| Theme | Revaluation of de nove cancer | |
|---|---|---|
| Title | History concerning diagnosis of de novo cancer | |
| Publish Date | 2009/07 | |
| Author | Shin-ei Kudo | Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author | Yuichi Mori | Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author | Nobunao Ikehara | Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author | Hiroshi Kashida | Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author | Shigeharu Hamatani | Department of Pathology, Showa University Northern Yokohama Hospital |
| [ Summary ] | The "adenoma-carcinoma sequence" is conventionally considered to be a primary factor in the development of colorectal cancer. However, depressed type early cancers are considered to emerge directly from normal mucosa without going through adenomas. In Japan, depressed type lesions, such as IIc are considered to be de novo cancers. There has been a great deal of discussion concerning de novo cancer. Compared to other macroscopic forms, depressed type lesions characteristically have a high possibility of being cancer contain and haning submucosal invasion. They also become invasive as early on while still small. Recently, the importance of depressed type lesions has been widely recognized not only in Japan, but also in the West. | |