| Theme | Update in management of colitic cancer | |
|---|---|---|
| Title | Histogenesis of colitis associated colorectal neoplasia | |
| Publish Date | 2009/05 | |
| Author | Yoichi Ajioka | Division of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Sciences, Niigata University |
| Author | Akito Iwanaga | Division of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Sciences, Niigata University |
| Author | Jun Watanabe | Division of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Sciences, Niigata University |
| Author | Ken Nishikura | Division of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Sciences, Niigata University |
| Author | Gen Watanabe | Division of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Sciences, Niigata University |
| Author | Takashi Kato | Division of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Sciences, Niigata University |
| [ Summary ] | Intramucosal colorectal neoplasias complicated by long-standing ulcerative colitis (UC) can be divided histologically into two groups ; ones which are in distinguishible from tumors found in the colorectum, and ones which display unique feature be compared to tumors in the ordinary colorectum. From the view point of cancer histogenesis, the former tumors may be thought to be related to the lineage of the following 1) adenoma-carcinoma sequence, 2) de novo cancerization, 3) serrated polyp neoplasia pathway, in the ordinary colorectum. The latter tumors are thought to be of specific histogenetic pathway in the inflammatory mucosa (colitis-carcinoma sequence). Intramucosal neoplasias, which are thought to developed through colitis-arcinoma sequence are grouped as follows by their histological features ; 1) well differentiated tumors (WDT) with surperficial differentiation, 2) WDT with abundant differentiated cells, 3) WDT without differentiated cells, 4) dedifferentiated type tumor (poorly differentiated adenocarcinoma, signet ring cell carcinoma), and 5) tumors which cannot be classified as either benign or malignant. Furthermore, these tumors display unique macroscopic features such as p53 protein overexpression, and cell kinetics as compared to the ordinary intramucosal neoplasia of colorectum. Tumors in the line of the colitis-carcinoma sequence and in the lines for ordinary cancer histogenesis may be differentiated pathologically by the combination of these three features and the histological findings. | |