| Theme | Frontier of image diagnosis for colorectal carcinoma | |
|---|---|---|
| Title | Autofluorescence Imaging videoendoscopy system in detection of colon polyps | |
| Publish Date | 2009/03 | |
| Author | Noriya Uedo | Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Disease |
| Author | Ryu Ishihara | Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Disease |
| Author | Hiroyasu Iishi | Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Disease |
| Author | Rika Chatani | Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Disease |
| Author | Takashi Kizu | Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Disease |
| Author | Takuya Inoue | Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Disease |
| Author | Noboru Hanaoka | Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Disease |
| Author | Yoji Takeuchi | Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Disease |
| Author | Koji Higashino | Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Disease |
| [ Summary ] | Autofluorescence Imaging (AFI) systems using a combination of autofluorescence and refl ected images can visualize colonic tumors as distinct purple areas on green backgrounds by differentiating tissues fluorescent properties. To investigate the feasibility of detection of colonic adenoma and adenocarcinoma, we conducted a randomized comparative study. A total of 64 patients were enrolled and were randomly assigned to AFI or white light groups. Patients distal sigmoid colons and rectums were examined under autofluorescence or white light followed by other modes of observation employed by endoscopists. The diagnostic capabilities of each method for detection of neoplasms was compared. The sensitivity and specificity of AFI for detection of neoplastic polyps was 84% and 60% , respectively. AFI detection rates were the same as those for white light colonoscopy : 90% and 64% . White light observation missed more flat lesions including one adenocarcinoma. AFI has the potential to detect more flat lesions but efficacy was unable to be demonstrated in the recto-sigmoid colon, as seen in restricted populations. Further investigations are needed to determine optimum usage. | |