| Theme | Aiming at the future of depressed type of lesion in early colorectal cancer | |
|---|---|---|
| Title | Developmental processes and malignancy of the colorectal cancers, derived from IIc type lesions | |
| Publish Date | 2008/11 | |
| Author | Hisashi Nakamura | Department of Gastroenterology, Chofu Surgical Clinic |
| Author | Yasuo Ohkura | Department of Pathology, Kyorin University School of Medicine |
| Author | Akihiko Yamamura | Department of Pathology, Tokyo Metropolitan Tama Cancer Detection Center |
| Author | Yasuhiro Oono | Department of Gastroenterology, Tokyo Metropolitan Tama Cancer Detection Center |
| [ Summary ] | We investigated 96 cases of colorectal cancer derived from IIc type early one (M ; 22 cases, SM1 ; 12 cases, SM2 ; 29 cases, SM3 ; 13 cases, MP ; 20 cases) clinicopathologically. Submucosal massive invasion of cancer cells is found from 5 mm in largest diameter. From the data analyzed the relationships between tumor diameter, depth of invasion and thickness of tumor nest, three courses of developmental processes are estimated ; pure growth pathways, protruded growth pathways and lateral growth pathways. From histopathological examinations, cancers in the pure growth pathway and the protruded growth pathway show a high prevalence of lymphovascular invasion and mixed, poorly differentiated cancer components, which are risk factors for lymph nodes metastasis. In SM2 and SM3 cancers, 95.2 % (40 / 42) were in the protruded growth pathway, which is thought to be the main root of the developmental processes for depressed type colorectal cancer. | |