| Theme | Small invasive cancer of colon and rectum less than 10 mm | |
|---|---|---|
| Title | Size not determining factor for grading invasiveness of early invasive colorectal cancer | |
| Publish Date | 2008/09 | |
| Author | Takahisa Matsuda | Division of Endoscopy, National Cancer Center Hospital |
| Author | Yutaka Saito | Division of Endoscopy, National Cancer Center Hospital |
| Author | Takeshi Nakajima | Division of Endoscopy, National Cancer Center Hospital |
| Author | Shigetaka Yoshinaga | Division of Endoscopy, National Cancer Center Hospital |
| Author | Tsuyoshi Kikuchi | Division of Endoscopy, National Cancer Center Hospital |
| Author | Shinsuke Kiriyama | Division of Endoscopy, National Cancer Center Hospital |
| Author | Tadakazu Shimoda | Division of Clinical Laboratory, National Cancer Center Hospital |
| Author | Takahiro Fujii | Fujii Clinic |
| [ Summary ] | A total of 583 consecutive early invasive colorectal cancers (EI-CRCs) treated with EMR or surgery at NCCH were enrolled in this study. Lesions were classifled into the following two groups based on their size for detailed analysis: small (<= 10 mm) and large (> 10 mm). Clinicopathological features, incidence of lymph node metastasis (LMN) and risk factors for LNM such as invasion depth, lymphovascular invasion (LVI) and poorly differentiated adenocarcinoma (PDA) were analyzed in all resected specimens. There were 120 (21 %) and 463 (79 %), small and large lesions respectively. Histopathological analysis of the small group revealed submucosal (SM) deep cancer (SM : > 1,000 Mum) in 90 (75 %) cases, LVI in 26 (22 %) cases and PDA in 12 (10 %) cases. Similarly, the large group exhibited sm deep cancer in 380 (82 %) cases, LVI in 125 (27 %) cases, and PDA in 79 (17 %) cases, respectively. Moreover, the rate of LNM was 11.2 % and 12.1 % in small and large groups, respectively. Small EI-CRCs demonstrate the same aggressiveness and malignancy potential as large lesions. | |