| Theme | Considering of the endoscopic classification in development of early colorectal cancer | |
|---|---|---|
| Title | Histological analysis of intra-mucosal growth patterns in early colorectal cancer, related to endoscopically observed growth patterns | |
| Publish Date | 2008/05 | |
| Author | Shigeharu Hamatani | Department of Pathology, Showa University Northern Yokohama Hospital |
| Author | Tomokazu Hisayuki | First Department of Pathology, Showa University |
| [ Summary ] | The aim of this study was to verify the validity of endoscopic classification of colorectal cancer growth patterns into three histologic types. The subjects consisted of 158 cases of colorectal cancer with massive invasion into the sub-mucosal layer. These growth forms were classified into three types (protruded, flat, and depressed) through endoscopic observation. Tumor growth forms were compared by examining elements which remained in the mucosa after histology. A determination was made as to whether tumor elements remained in the mucosa after histology by using desmin immunostaining. Tumorous elements in the mucosa were present in 75 % of the subjects. The residual ratio for tumorous elements in the mucosa in the depressed type was 50 % or less. The residual ratio was especially low in type Is + IIc depressed cancer. In type IIa + IIc, tumor elements in the mucosa often exhibited the depressed form. Endoscopically observed growth patterns tended to be classified similarly to those classified through histology in terms of tumor element growth patterns in the mucosa. | |