| Theme | Development of surveillance methods for colitic cancer -- From pit pattern to molecular biology | |
|---|---|---|
| Title | Chromoendoscopy and the diagnosis of dysplasia in ulcerative colitis surveillance | |
| Publish Date | 2007/01 | |
| Author | Matt Rutter | Consultant Gastroenterologist, University Hospital of North Tees |
| [ Summary ] | Abstract : Patients with longstanding extensive ulcerative colitis are at increased risk of developing colorectal cancer. Colonoscopic surveillance in colitis relies on the detection of premalignant dysplastic tissue. However the neoplastic lesions are often subtle and easily overlooked or confused with non neoplastic changes. Chromoendoscopy (endoscopic dye-spraying of the gastrointestinal tract) improves lesion detection by highlighting subtle mucosal changes, permitting targeted biopsies of these lesions. In addition, when combined with magnifying endoscopes, detected lesions can be assessed in vivo, and categorised as neoplastic or non-neoplastic, enabling tailored endoscopic therapy for appropriate lesions. This paper reviews the current colitis surveillance literature on chromoendoscopy for lesion detection and characterisation. |
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