INTESTINE Vol.11 No.1(3-2)

Theme Development of surveillance methods for colitic cancer -- From pit pattern to molecular biology
Title Surveillance methods and pit pattern diagnosis for ulcerative colitis associated cancer and dysplasia
Publish Date 2007/01
Author Ichiro Hirata Department of Gastroenterology, Fujita Health University
Author Ken Toshina
Author Mitsuyuki Murano
[ Summary ] Ordinary surveillance colonoscopy with multiple random biopsies has recently come to thought ineffective, because the detectability of cancer or dysplasia is quite low with many biopsies. Therefore, other surveillance methods are deemed to be necessary. An effort was made to develop surveillance colonoscopic techniques, using chromo and magnifying colonoscopy, by employing targeting biopsies in forty-five long term ulcerative colitis cases. Consequently, seven cases with dysplasia or colon cancer were detected. The pit patterns associated with the lesions were the IIIL, IV and VI type. There was no prevalence of pit patterns in LGD, HGD or cancer cases.
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