| Theme | Liver and Immunology 2019 | |
|---|---|---|
| Title | Molecular Mechanism of Primary Biliary Cholangitis | |
| Publish Date | 2019/05 | |
| Author | Shinji Shimoda | Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University |
| [ Summary ] | Molecular mimicry as an autoimmune disease onset mechanism has been proposed as the trigger for PBC (primary biliary cholangitis). Now it is understood that Interferon Gamma production from activated T cells and the environment around the bile ducts such as innate immune ligands or hydrophobic bile acids are the factors that construct the pathophysiology of PBC. Furthermore, bile ducts as targets themselves contribute to the pathophysiology as produce cytokines and chemokines and as release autoantigens. Hereafter we must clarify the molecular mechanism of Ursodeoxycholic Acid treatment failure and identify the treatment target molecules. | |