| Theme | Reconsideration of Gastritis | |
|---|---|---|
| Title | Characteristics of Gastric Cancers without Helicobacter pylori Infection and Association with the Background Mucosa | |
| Publish Date | 2019/12 | |
| Author | Daisuke Yoshimura | Division of Gastroenterology, Saiseikai Fukuoka General Hospital |
| Author | Rie Yoshimura | Medical Checkup Center Wellness |
| Author | Seiya Kato | Division of Pathology, Saiseikai Fukuoka General Hospital |
| Author | Yusuke Kitagawa | Division of Gastroenterology, Saiseikai Fukuoka General Hospital |
| Author | Kayoko Nakano | Division of Gastroenterology, Saiseikai Fukuoka General Hospital |
| Author | Toshiaki Ochiai | Division of Gastroenterology, Saiseikai Fukuoka General Hospital |
| [ Summary ] | Between April 2005 and December 2018, we retrospectively investigated cases of gastric cancer without Helicobacter pylor(HP) infection, and 61 patients who met the criteria for HP‒uninfected cases based on laboratory investigations, endoscopic and histopathological diagnosis were enrolled in the study. Interestingly, most patients were classified into three categories as follows: the first category included those with cancer of the gastric cardia or the gastroesophageal junction. The second category included patients with well‒differentiated adenocarcinoma, all of which were superficial cancers located in the fundic gland region. Histopathologically, the appearance and immunohistochemical phenotype resembled the foveolar epithelium, fundic glands, pseudopyloric glands, or a combination of these. The third category included signet‒ring cell carcinomas located in the transitional zone of the fundic and pyloric glands. Most carcinomas presented as flat whitish lesions restricted to the mucosa. Our study indicated that gastric cancer without HP infection can be classified into at least three distinct categories that are closely associated with the gastric region and background mucosa. |
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