| Theme | IPMN/Pancreatic Cyst as an Increasing Common Disease -- Current Status and Issues | |
|---|---|---|
| Title | Pathology of Intraductal Papillary Mucinous Neoplasm (IPMN) | |
| Publish Date | 2019/11 | |
| Author | Eriko Ikeda | Department of Internal Medicine, Division of Pathology, Jichi Medical University / Department of Internal Medicine, Division of Gastroenterology, Jichi Medical University |
| Author | Noriyoshi Fukushima | Department of Internal Medicine, Division of Pathology, Jichi Medical University |
| [ Summary ] | In recent years, intraductal papillary mucinous neoplasm (IPMN) has increased and the pathological concept has been established. Histological grading and subtyping are important for pathologic diagnosis in IPMN. IPMNs are classified into low grade (same as "adenoma") and high grade (same as "non‒invasive carcinoma") according to their histological atypia, and into gastric, intestinal, pancreatobiliarty and oncocytic subtypes based on their cellular differentiation. MUC stains are useful for their histological subtyping. IPMN frequently harbor somatic mutations in GNAS, KRAS and RNF43 genes. GNAS gene mutation is relatively specific molecular alterations in IPMN and is uncommonly detected in pancreatic ductal carcinoma (PDAC). Pancreatic juice cytology with MUC Stains was reported to be useful for preoperative decision making. | |