| Theme | Chronic Constipation : A New Classification, Pathophysiology, Diagnosis, Treatment | |
|---|---|---|
| Title | New Drugs for Treating Constipation : Secreting Water into The Instestinal Lumen | |
| Publish Date | 2018/04 | |
| Author | Masashi Oka | Department of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University |
| [ Summary ] | Several new drugs are currently available for treating constipation. Lubiprostone, a ClC‒2 chloride channel activator, and linaclotide, a guanylate cyclase C‒receptor antagonist, work through the mechanism of secreting water into the small intestine lumen. These drugs are suitable for use by elderly patients and those who are using psychoactive drugs. | |