| Theme | Diagnosis and Treatment of Non-ampullary Duodenal Epithelial Tumor -- Current Status and Issues | |
|---|---|---|
| Title | Clinicopathological Features of Superficial Non-ampullary Duodenal Epithelial Tumors | |
| Publish Date | 2018/09 | |
| Author | Takahito Toba | Division of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University Omori Medical Center |
| Author | Yosuke Okamoto | Division of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University Omori Medical Center / Department of Gastroenterology, Toranomon Hospital |
| Author | Daisuke Kikuchi | Department of Gastroenterology, Toranomon Hospital |
| Author | Toshiro Iizuka | Department of Gastroenterology, Toranomon Hospital |
| Author | Shu Hoteya | Department of Gastroenterology, Toranomon Hospital |
| Author | Yoshinori Igarashi | Division of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University Omori Medical Center |
| [ Summary ] | Superficial non-ampullary duodenal epithelial tumors (SNADETs) are relatively rare; however, lately these are being detected more commonly owing to advances in endoscopic technology. Nevertheless, the pathological nature of SNADETs remains unclear, and to date, an optimal management strategy has not been established for these tumors. We performed a retrospective analysis of 138 endoscopically resec ted SNADETs to gain a better understanding of the clinicopathological features. Lesions were classified into 2 groups: low-grade adenomas (LGA) (71 lesions, 51.4 %) and high-grade adenomas/carcinoma (HGA/Ca) (67 lesions, 48.6 %). Immunohistochemical analysis showed MUC5AC (p=0.002) and MUC6 (p<0.001) were significantly more commonly expressed and CD10 (p=0.002) and CDX2 (p=0.029) were significantly less commonly expressed in HGA/Ca lesions. Multivariate regression analysis showed that MUC6 expression (p=0.001) was an independent risk factor for the classification of HGA/Ca. The gastric phenotype of adenocarcinoma may be linked to the malignant potential of SNADETs. |
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