| Theme | Progress in Endoscopic Ultrasonography for Biliopancreatic Diseases | |
|---|---|---|
| Title | EUS—guided Celiac Plexus Neurolysis/Celiac Ganglia Neurolysis | |
| Publish Date | 2017/07 | |
| Author | Kosuke Minaga | Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine |
| Author | Masayuki Kitano | Second Department of Internal Medicine, Wakayama Medical University School of Medicine |
| Author | Takeshi Miyata | Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine |
| Author | Hajime Imai | Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine |
| Author | Mamoru Takenaka | Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine |
| Author | Masatoshi Kudo | Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine |
| [ Summary ] | Cancer pain, secondary to upper abdominal malignancies, is often difficult to control and poses a challenge to physicians. Non‒steroidal anti‒inflammatory drugs and opioids are recommended painkillers for severe cancer pain according to the World Health Organization cancer pain ladder ; however, these are not always effective and some patients develop drug complications. Celiac plexus neurolysis (CPN) consists of chemical ablation, and can be used as a treatment to help patients endure pain caused by abdominal malignancies. EUS‒guided CPN (EUS‒CPN) was first described in 1996 and is a currently widely applied to treat upper abdominal cancer‒associated pain. This technique is theoretically safer than posterior percutaneous CPN, as EUS provides detailed Doppler imaging of the blood vessels, particularly of those surrounding the gastrointestinal tract lumen. Recently, different EUS approaches such as EUS‒guided celiac ganglia neurolysis (EUS‒CGN) and EUS‒guided broad plexus neurolysis (EUS‒BPN) were developed to improve the efficacy of this technique. The potential and efficacy of these techniques have drawn attention and many articles regarding EUS‒guided neurolysis have been published over the last decade. | |