| Theme | Roles and Importance of Microbiota in Clinical Medicine | |
|---|---|---|
| Title | Gut Microbiota and Abnormal Bowel Habit/Irritable Bowel Syndrome | |
| Publish Date | 2017/09 | |
| Author | Motoyori Kanazawa | Department of Behavioral Medicine, Tohoku University Graduate School of Medicine |
| Author | Shin Fukudo | Department of Behavioral Medicine, Tohoku University Graduate School of Medicine |
| [ Summary ] | Gut microbiota dysbiosis may play an important role in the development of functional gastrointestinal disorders (FGID), including irritable bowel syndrome (IBS). Recent evidence has suggested that an altered brain‒gut‒microbiota axis may be key in the pathophysiology of FGID. Although it has been previously reported that patients with IBS or chronic idiopathic constipation show different composition of gut microbiota, it is still unclear which bacteria acts as a pathogen in FGID. Promising treatments for FGID would involve rebalancing the altered gut microbiota through diet, probiotics, antibiotics, or fecal microbiota transplantation (FMT). | |