| [ Summary ] |
Diverticulosis is a well‒known common disease of the colon, the incidence of which has markedly increased worldwide. We reviewed the medical data of 62,503 general asymptomatic colonoscopy examinees (47,325 men and 15,178 women ; age, 52.1±9.2 years) from 1990 to 2010 in Japan. Diverticulosis was detected in 11,771 subjects (18.8 %), The incidence rates of diverticulosis in 1990‒2000 and 2001‒2010 were 13.0 % (3,771/29,071) and 23.9 % (8,000/33,432), respectively. The incidence of left‒sided colorectal diverticula markedly increased with age but did not significantly change with time. The most recent 3,327 colonoscopy examinees (age, 55.0±9.1 years) were further analyzed with 16 background factors. Diverticulosis was detected in 858 subjects (25.8 %), which comprised 734 men (29.5 % of 2,485 men) and 124 women (14.7 % of 842 women). In the multiple logistic analysis, the calculated odds ratios (ORs) indicated that age (OR=1.24‒1.96), male sex (OR=1.20), smoking (OR=1.15‒1.22), severe weight increase in adulthood (OR=1.17), HbA1c leve (l OR=1.15), alcohol drinking（OR＝1.11）, and serum triglyceride level (OR=1.10) were significantly positively associated with the development of diverticulosis. In conclusion, the large‒scale data of asymptomatic colonoscopy examinees indicated that the prevalence of diverticulosis continues to increase in Japan. Age, male sex, smoking, severe weight increase in adulthood, serum HbA1c level, alcohol drinking, and serum triglyceride level showed a significant positive association with diverticulosis. |