| Theme | Hepatitis B : Towards the Elimination | |
|---|---|---|
| Title | The Japanese Society of Hepatology Guidelines for Hepatitis B Virus Infection Management | |
| Publish Date | 2016/03 | |
| Author | Masayuki Kurosaki | Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital |
| Author | Namiki Izumi | Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital |
| [ Summary ] | The ultimate goal of antiviral therapy for chronic hepatitis B is HBs antigen clearance. A finite duration of therapy with pegylated interferon could achieve high rates of HBs antigen clearance among responders ; however, the percentage of responders is limited to 20 % to 40 %. Entecavir and tenofovir administration could achieve a high rate of HBV DNA negativity, meanwhile the rate of HBs antigen clearance is also high in tenofovir treated patients. In patients with a suboptimal response, combination therapy using tenofovir plus entecavir or lamivudine is recommended. | |