| Theme | New Development of Laterally Spreading Tumor | |
|---|---|---|
| Title | Clinicopathological Findings and Molecular Alterations in Colorectal Laterally Spreading Tumors | |
| Publish Date | 2015/08 | |
| Author | Tamotsu Sugai | Division of Molecular Diagnostic Pathology, Department of Pathology, School of Medicine, Iwate Medical University |
| Author | Noriyuki Uesugi | Division of Molecular Diagnostic Pathology, Department of Pathology, School of Medicine, Iwate Medical University |
| Author | Makoto Eizuka | Division of Molecular Diagnostic Pathology, Department of Pathology, School of Medicine, Iwate Medical University |
| Author | Yayoi Takahashi | Division of Molecular Diagnostic Pathology, Department of Pathology, School of Medicine, Iwate Medical University |
| Author | Noriyuki Arakawa | Division of Molecular Diagnostic Pathology, Department of Pathology, School of Medicine, Iwate Medical University |
| Author | Takayuki Matsumoto | Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University |
| [ Summary ] | Colorectal laterally spreading tumors (LST) have been classified into LST‒G (granular) and LST‒NG (non‒granular). Previous studies have shown that colorectal LSTs have distinct clinicopathological features and a high malignant potential. The aims of this study were to clarify the clinicopathological features and molecular findings of colorectal LSTs. The frequency of submucosal invasion was high in the specific type of LST. Significant differences in the frequency of KRAS and APC mutations were found in the LST‒G type ; whereas, distinct molecular features were not defined in the LST‒NG type. DNA methylation was a common molecular feature in both LST‒Gs and LST‒NGs. The molecular and clinicopathological findings suggest that LST‒Gs and LST‒NGs have different molecular mechanisms involved in colorectal tumorigenesis. | |