| Theme | Unraveling of the Pathophysiology of Functional Gastrointestinal Disorders and Updated Treatments | |
|---|---|---|
| Title | Medication for Functional Dyspepsia -- Effectiveness of Acid Suppressive Agent and Prokinetic Agent | |
| Publish Date | 2015/02 | |
| Author | Mototsugu Kato | Division of Endoscopy, Hokkaido University Hospital |
| Author | Shouko Ono | Division of Endoscopy, Hokkaido University Hospital |
| Author | Katsuhiro Mabe | Department of Cancer Preventive Medicine, Hokkaido University Graduate School of Medicine |
| Author | Shuichi Miyamoto | Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine |
| Author | Ken Mizushima | Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine |
| Author | Masayoshi Ohno | Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine |
| Author | Saori Omori | Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine |
| Author | Momoko Tsuda | Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine |
| Author | Masakazu Takahashi | Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine |
| Author | Yuichi Shimizu | Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine |
| Author | Naoya Sakamoto | Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine |
| [ Summary ] | Since functional dyspepsia (FD) has a complicated physiology, several drugs have been used in its treatment. Acid suppressive agents and prokinetic agents are used for the first‒line therapy of FD. In a meta‒analysis of randomized controlled studies, proton pump inhibitors, histamine receptor antagonists, and 5‒HT4 agonists demonstrated significant improvement of FD symptoms compared with placebo. The clinical practice guidelines for functional dyspepsia created by the Japanese Society of Gastroenterology recommend acid suppressants and prokinetics for the initial treatment of FD ; acotiamide is the only drug indicated for the treatment of FD that is reimbursed by the Japanese public health insurance system. | |